Among the most substantial weight reductions seen in any obesity medication to date
Some participants lost over 24% of body weight at 48 weeks
Works by suppressing appetite, improving satiety, and increasing energy expenditure
Strong reduction in HbA1c in patients with type 2 diabetes
Enhances insulin secretion and reduces glucose production
May help reduce or eliminate the need for other diabetes medications in some individuals
Reduction in visceral fat
Lower fasting glucose and insulin levels
Improved markers of cardiometabolic health (cholesterol, triglycerides)
Weight loss + improved metabolic profile may translate to reduced cardiovascular risk
Formal cardiovascular outcome trials are still needed
Significant reductions in liver fat
Shows promise for treating metabolic-associated steatohepatitis (MASH / fatty liver disease)
Unlike many weight‑loss medications, retatrutide stimulates glucagon receptors, which can increase calorie burning
intended strictly for laboratory research use and is not for human consumption or clinical application.
Among the most substantial weight reductions seen in any obesity medication to date
Some participants lost over 24% of body weight at 48 weeks
Works by suppressing appetite, improving satiety, and increasing energy expenditure
Strong reduction in HbA1c in patients with type 2 diabetes
Enhances insulin secretion and reduces glucose production
May help reduce or eliminate the need for other diabetes medications in some individuals
Reduction in visceral fat
Lower fasting glucose and insulin levels
Improved markers of cardiometabolic health (cholesterol, triglycerides)
Weight loss + improved metabolic profile may translate to reduced cardiovascular risk
Formal cardiovascular outcome trials are still needed
Significant reductions in liver fat
Shows promise for treating metabolic-associated steatohepatitis (MASH / fatty liver disease)
Unlike many weight‑loss medications, retatrutide stimulates glucagon receptors, which can increase calorie burning
intended strictly for laboratory research use and is not for human consumption or clinical application.